产品货号：
Z28062
中文名称：
TAF1抗体
英文名称：
Anti-TAF1 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TAF1 Antibody |
| 指标别名 | BA2R;CCG1;CCGS;Cell cycle gene 1 protein;DYT3;KAT4;N TAF1;NSCL2;OF;P250;TAF(II)250;TAF1;TAF1-Specific;TAF2A;TAFII 250;TAFII250;TBP associated factor 250kDa |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ChIP,ELISA,WB |
| 基因名称 | TAF1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of human TAF1. |
| 计算分子量 | 213kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against human TAF1 protein.The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.?A BLAST analysis was used to suggest cross-reactivity with TAF1 protein from human,mouse and rat based on 100% homology with the immunizing sequence.Reactivity against homologues from other sources is not known. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Anti-TAF1 antibody is suitable for Cancer,Immunology and Nuclear Signaling research.Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex,which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors.TFIID nucleates the formation of transcription pre-initiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II.TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors.For example,TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue,leading to MDM2-mediated degradation of TP53.?TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1).The retinoblastoma tumor suppressor protein,RB1,interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity.TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18% of mammalian genes. |
| Uniprot ID | P21675 |
| 基因名全称 | Transcription initiation factor TFIID subunit 1 |
| 推荐稀释比 | ELISA:1:150,000 - 1:300,000 ChIP:User Optimized IHC:10μg/mL IP:User Optimized WB:1:100 - 1:2,000 |
相关搜索：TAF1抗体，TAF1多抗，Anti-TAF1 Antibody